Since Penoxycyline is an extremely potent medicine, it should be taken cautiously (usually one pill per five days), or it will cause overdose. I slowly increased to Tech III by using only a Grade School and a City College. If its not green, put more education in your city, or you can acutely effect tech by putting colleges adjacent or very close to your industry. It fully heals such diseases as malaria, sleeping sickness or plague. Look at the Tech Level map overlay, which will tell you the progress your industry is gaining in tech. I guess its not terrible in practice as it stands, but it basically means that tribal very slow research progress through the entire game + the slow initial tech start.
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